Cell
& Molecular Biology
Welcome
from the Program Director
About
the Program
Faculty
Courses
Doctor
of Philosophy
Research
|
Faculty
Research Interests
Please select a category:
Regulation of Gene Expression
Molecular Mechanisms in Development
Cell Structure/Function
Relationships
Cell Cycle and Growth Control
Receptors and Signal
Transduction
Structural Analysis
of Macromolecules
Extracellular Matrix and
Gene Expression
Calcium and Calcium-binding
Proteins
Molecular Basis of Disease
Note
that these catogories are necessarily broad and loosely defined. More
information is available under the individual's listing and on their
web pages (if implemented.)
Faculty
working on Regulation of Gene Expression:
- J.
Krzysztof Blusztajn, PhD
- Professor
of Pathology & Laboratory Medicine, Professor of Psychiatry
- Acetylcholine
synthesis and release; signal transduction by lipid second messengers
- Stephen
Farmer, Ph.D.
- Professor
of Biochemistry.
- Tissue-specific
gene expression; role of matrix interactions and cell morphology.
- Sue
Fisher, Ph.D.
- Associate
Professor of Microbiology.
- Molecular
genetics and regulation of nitrogen assimilation in B. subtilis.
- Judith
Foster, Ph.D.
- Professor
of Biochemistry.
- Regulation
of elastic fiber gene expression in the development and repair
of pulmonary and cardiovascular tissues.
- Eva
Kashket, PhD
- Professor
of Microbiology
- Regulation
of solvent production and endospore formation, genetic instability
in saccharolytic Clostridia
- Katya
Ravid, Ph.D.
- Associate
Professor of Biochemistry.
- Genetic
and signaling mechanisms regulating blood cell development; vascular
biology.
- Shelley
Russek, Ph.D.
- Assistant
Professor of Pharmacology.
- Gene
expression in neurons/tissue specific promoters as targets for
therapeutic agents
- Barbara
Schreiber, PhD
- Associate
Professor of Biochemistry
- Atherosclerosis
and aortic smooth-muscle cells; the effect of atherogenic lipoproteins
on cell proliferation and biosynthesis of collagens and apolipoproteins
- Barbara
D. Smith, PhD
- Professor
of Biochemistry
- Changes
in gene expression of connective-tissue components associated
with transformation and differentiation
- Guillermo
Taccioli, PhD
- Assistant
Professor of Microbiology
- Lymphocyte
development; V(D) J recombination; DNA repair
- Gregory
A. Viglianti, Ph.D.
- Assistant
Professor of Microbiology.
- Molecular
biology of HIV-1; the role of virus-host cell interactions in
pathogenesis.
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Faculty
working on Molecular Mechanisms in Development:
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- J.
Fernando Garcia-Diaz, PhD
- Associate
Professor of Physiology
- Ion
channels in developing cochlea; intracellular calcium response
to angiotensin II
- Eva
Kashket, PhD
- Professor
of Microbiology
- Regulation
of solvent production and endospore formation, genetic instability
in saccharolytic Clostridia
- Thomas
Rothstein, M.D., Ph.D.
- Professor
of Medicine and Microbiology.
- Regulation
of apoptosis, B1 lymphocyte development, and surface receptor
signaling and transcriptional activation.
- Julie
H. Sandell, Ph.D.
- Associate
Professor of Anatomy and Neurobiology
- Development
and inherited degeneration in zebrafish and primate retina.
- Raymond
Stephens, Ph.D.
- Professor
of Physiology.
- Microtubule
assembly and membrane dynamics; ciliary and flagellar movement.
- Karen
Symes, Ph.D.
- Assistant
Professor of Biochemistry.
- Role
of cell-cell interactions in embryonic development.
- Vassilis
I. Zannis, PhD
- Professor
of Biochemistry
- Mechanisms
of transcriptional regulation of the apolipoprotein genes in
vivo and in vitro using transgenic mice, adenovirus-mediated
gene transfer, and antisense methodologies. Signal transduction
pathways involved in the activation of the apolipoprotein gene
promoters.
Faculty
working on Cell Structure/Function Relationships:
- Iih-Nan
(George) Chou, Ph.D.
- Professor
of Microbiology.
- Cytoskeletal
perturbations and mechanisms of cell injury by carcinogenic metal
ions.
- R.
B. Corley, Ph.D.
- Professor
of Microbiology.
- B-cell
differentiation; immunoglobulin assembly; antibody structure/function.
- M.
Carter Cornwall, Ph.D.
- Professor
of Physiology.
- Visual
transduction and light adaptation in rods and cones of the vertebrate
retina
- Carlos
B. Hirschberg, PhD
- Professor
of Molecular and Cell Biology
- Novel
Regulation of Posttranslational Modifications in Mammals and Yeast.
- Herbert
Kagan, PhD
- Professor
of Biochemistry
- Mechanisms
of action, regulation, and molecular biology of amine oxidases,
with emphasis on connective-tissue lysyl oxidase.
- Judith
Saide, Ph.D.
- Associate
Professor of Physiology.
- Organization
of Z-band proteins in Drosophila flight muscle
- Elizabeth
Simons, PhD
- Professor
of Biochemsitry
- Platelet-endothelium
interactions in Alzheimer's disease; stimulus responses
in blood cells and acquisition of such responses as precursor
cells mature
- Philip
Trackman, PhD
- Assistant
Professor of Periodontology and Oral Biology and Biochemistry
- Gene
regulation in gingival and mineralized tissues
Faculty
working on Cell Cycle and Growth Control:
- Claudia
Abeijon, PhD
- Assistant
Professor of Molecular and Cell Biology
- Biosynthesis
of Yeast Cell Wall Polymers
- David
M. Larson, PhD
- Associate
Professor of Pathology & Laboratory Medicine
- Molecular
controls and functions of gap junction proteins in vascular physiology
and disease.
- Katya
Ravid, Ph.D.
- Associate
Professor of Biochemistry.
- Genetic
and signaling mechanisms regulating blood cell development; vascular
biology.
- Jacqueline
Sharon, PhD
- Professor
of Pathology & Laboratory Medicine
- Generation
and use of polyclonal antibody libraries for therapeutics and
diagnostics; soluble factors controling tumor growth.
- Gail
Sonenshein, Ph.D.
- Professor
of Biochemistry.
- Role
of oncogenes in control of cell proliferation, apoptosis, and
neoplastic transformation.
-
Faculty
working on Receptors and Signal Transduction:
- J.
Krzysztof Blusztajn, PhD
- Professor
of Pathology & Laboratory Medicine, Professor of Psychiatry
- Acetylcholine
synthesis and release; signal transduction by lipid second messengers
- Barbara
E. Corkey, PhD
- Professor
of Medicine and Biochemistry
- Metabolic
regulation of signal transduction, calcium handling and fatty
acyl CoA in pancreatic beta-cells and fat cells
- M.
Carter Cornwall, Ph.D.
- Professor
of Physiology.
- Visual
transduction and light adaptation in rods and cones of the vertebrate
retina
- Theresa
Davies, PhD
- Assistant
Professor of Biochemistry
- Signal
transduction in platelets, Amyloid Precursor Protein (APP) processing,
and platelet-endothelium interactions in patients with Alzheimer's
disease.
- J.
Fernando Garcia-Diaz, PhD
- Associate
Professor of Physiology
- Ion
channels in developing cochlea; intracellular calcium response
to angiotensin II
- Terrell
Gibbs, Ph.D.
- Assistant
Professor of Pharmacology.
- Modulators
of amino acid receptor function in the brain.
- James
Head, Ph.D.
- Professor
of Physiology.
- Regulatory
role of high affinity intracellular calcium binding proteins.
- Konstantin
Kandror, PhD
- Assistant
Professor of Biochemistry
- Regulated
vesicular traffic in different eukaryotic cells.
- Simon
Levy, PhD
- Associate
Professor of Physiology
- Intracellular
calcium regulation and detection; role of calcium in the excitability
of nerve cells and phototransduction.
- Joseph
Loscalzo, MD, PhD
- Professor
of Medicine and Biochemistry
- Endothelial
cells, platelet function, related to nitric oxide and atherothrombotic
mechanisms
- Richard
Mandel, PhD
- Associate
Professor of Pathology & Laboratory Medicine, Assistant Professor
of Biochemistry
- Biologic
functions of membrane associated protein disulfide isomerase
- Enrico
Nasi, Ph.D.
- Professor
of Physiology.
- Ion
channels, mechanisms of visual transduction and adaptation, calcium
signalling in photoreceptor cells.
- Matthew
Nugent, Ph.D.
- Associate
Professor of Biochemistry and Opthalmology.
- Cell
proliferation, growth factor-receptor interactions, proteoglycans,
extracellular matrix.
- Rahul
Ray, PhD
- Associate
Professor of Medicine and Physiology
- Structure-activity
of binding proteins and transcriptional factors related to vitamin
D endocrine system: protein crystallography/binding site mapping/molecular
modeling/mutational-analysis/gene-regulation
- Thomas
Rothstein, M.D., Ph.D.
- Professor
of Medicine and Microbiology.
- Regulation
of apoptosis, B1 lymphocyte development, and surface receptor
signaling and transcriptional activation.
- Neil
Ruderman, Ph.D., D.Phil.
- Professor
of Physiology.
- Insulin
action, gene expression, and diacylglycerol protein kinase C in
skeletal muscle.
- Shelley
Russek, Ph.D.
- Assistant
Professor of Pharmacology.
- Gene
expression in neurons/tissue specific promoters as targets for
therapeutic agents.
- Elizabeth
Simons, PhD
- Professor
of Biochemsitry
- Platelet-endothelium
interactions in Alzheimer's disease; stimulus responses
in blood cells and acquisition of such responses as precursor
cells mature
- Raymond
Stephens, Ph.D.
- Professor
of Physiology.
- Microtubule
assembly and membrane dynamics; ciliary and flagellar movement.
- Keith
Tornheim, PhD
- Associate
Professor of Biochemistry
- Metabolic
oscillations in fuel stimulated insulin secretion from pancreatic
beta-cells; altered fuel metabolism and nitric oxide production
in vascular disease in diabetes
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Faculty
working on Stuctural Analysis of Macromolecules:
- R.
B. Corley, Ph.D.
- Professor
of Microbiology.
- B-cell
differentiation; immunoglobulin assembly; antibody structure/function.
- James
A. Hamilton, PhD
- Professor
of Biophysics
- Lipid/protein
interactions and lipid/membrane dynamics
- James
Head, Ph.D.
- Professor
of Physiology.
- Regulatory
role of high affinity intracellular calcium binding proteins.
- C.
James McKnight, Ph.D.
- Assistant
Professor of Biophysics.
- Protein
structure/function and folding using NMR.
- Rahul
Ray, PhD
- Associate
Professor of Medicine and Physiology
- Structure-activity
of binding proteins and transcriptional factors related to vitamin
D endocrine system: protein crystallography/binding site mapping/molecular
modeling/mutational-analysis/gene-regulation
- Vassilis
I. Zannis, PhD
- Professor
of Biochemistry
- Structure
and function of human apoE, apoA-I and apoB; genetic variation
and post-translational modification.
Faculty
working on Extracellular Matrix and Gene Expression:
- Claudia
Abeijon, PhD
- Assistant
Professor of Molecular and Cell Biology
- Biosynthesis
of Yeast Cell Wall Polymers
- Judith
Foster, Ph.D.
- Professor
of Biochemistry.
- Regulation
of elastic fiber gene expression in the development and repair
of pulmonary and cardiovascular tissues.
- Herbert
Kagan, PhD
- Professor
of Biochemistry
- Mechanisms
of action, regulation, and molecular biology of amine oxidases,
with emphasis on connective-tissue lysyl oxidase.
- Matthew
Nugent, Ph.D.
- Associate
Professor of Biochemistry and Opthalmology.
- Cell
proliferation, growth factor-receptor interactions, proteoglycans,
extracellular matrix.
- Barbara
Schreiber, PhD
- Associate
Professor of Biochemistry
- Atherosclerosis
and aortic smooth-muscle cells; the effect of atherogenic lipoproteins
on cell proliferation and biosynthesis of collagens and apolipoproteins
- Barbara
D. Smith, PhD
- Professor
of Biochemistry
- Changes
in gene expression of connective-tissue components associated
with transformation and differentiation
- Gail
Sonenshein, Ph.D.
- Professor
of Biochemistry.
- Role
of oncogenes in control of cell proliferation, apoptosis, and
neoplastic transformation.
- Phillip
Stone, PhD
- Professor
of Biochemistry
- The
connective-tissue protein, elastin; its enzymatic destruction
and repair in vitro and in vivo, associated with pathologic processes
- Philip
Trackman, PhD
- Assistant
Professor of Periodontology and Oral Biology and Biochemistry
- Gene
regulation in gingival and mineralized tissues
- Vickery
E. Trinkaus-Randall, PhD, Program Director
- Associate
Professor of Ophthalmology, Associate Professor of Biochemistry
- Regulation
of proteoglycans in response to growth factors and regulation
of calcium signaling and phosphorylation in response to injury
Faculty
working on Calcium and Calcium-binding Proteins:
- Barbara
E. Corkey, PhD
- Professor
of Medicine and Biochemistry
- Metabolic
regulation of signal transduction, calcium handling and fatty
acyl CoA in pancreatic beta-cells and fat cells
- Richard
Fine, PhD
- Professor
of Biochemistry
- Neuronal
cell biology.
- Robin
Johnson, PhD
- Assistant
Research Professor of Biochemistry
- Calcium
and calcium regulation in neurons, emphasizing the role of the
endoplasmic reticulum and its constituent proteins.
- Benjamin
Kaminer, MB, BCh
- Professor
of Physiology
- Role
of endoplasmic reticulum, with emphasis on storage and release
of calcium
- Simon
Levy, PhD
- Associate
Professor of Physiology
- Intracellular
calcium regulation and detection; role of calcium in the excitability
of nerve cells and phototransduction.
- Enrico
Nasi, Ph.D.
- Professor
of Physiology.
- Ion
channels, mechanisms of visual transduction and adaptation, calcium
signalling in photoreceptor cells.
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Faculty
working on The Molecular Basis of Disease:
- Carmela
R. Abraham, PhD
- Associate
Professor of Biochemistry and Medicine
- Amyloid
and inflammation in the brain during normal aging and Alzheimer's
disease
- Peter
Brecher, Ph.D.
- Professor
of Biochemistry.
- Effect
of hypertension on gene expression in the cardiovascular system.
- Iih-Nan
(George) Chou, Ph.D.
- Professor
of Microbiology.
- Cytoskeletal
perturbations and mechanisms of cell injury by carcinogenic metal
ions.
- Richard
A. Cohen, MD
- Professor
of Medicine and Physiology
- Nitric
oxide regulation of vascular cells, oxidative stress, and atherosclerosis.
- Barbara
E. Corkey, PhD
- Professor
of Medicine and Biochemistry
- Metabolic
regulation of signal transduction, calcium handling and fatty
acyl CoA in pancreatic beta-cells and fat cells
- Theresa
Davies, PhD
- Assistant
Professor of Biochemistry
- Signal
transduction in platelets, Amyloid Precursor Protein (APP) processing,
and platelet-endothelium interactions in patients with Alzheimer's
disease.
- Stephen
Farmer, Ph.D.
- Professor
of Biochemistry.
- Tissue-specific
gene expression; role of matrix interactions and cell morphology.
- James
A. Hamilton, PhD
- Professor
of Biophysics
- Lipid/protein
interactions and lipid/membrane dynamics
- Carlos
B. Hirschberg, PhD
- Professor
of Molecular and Cell Biology
- Novel
Regulation of Posttranslational Modifications in Mammals and Yeast.
- Jianming
Hu, MD, PhD
- Assistant
Professor of Microbiology
- Viral
replication and pathogenesis; virus-host interactions
- Robin
Johnson, PhD
- Assistant
Research Professor of Biochemistry
- Calcium
and calcium regulation in neurons, emphasizing the role of the
endoplasmic reticulum and its constituent proteins.
- Konstantin
Kandror, PhD
- Assistant
Professor of Biochemistry
- Regulated
vesicular traffic in different eukaryotic cells.
- David
M. Larson, PhD
- Associate
Professor of Pathology & Laboratory Medicine
- Molecular
controls and functions of gap junction proteins in vascular physiology
and disease.
- Joseph
Loscalzo, MD, PhD
- Professor
of Medicine and Biochemistry
- Endothelial
cells, platelet function, related to nitric oxide and atherothrombotic
mechanisms
- Richard
Mandel, PhD
- Associate
Professor of Pathology & Laboratory Medicine, Assistant Professor
of Biochemistry
- Biologic
functions of membrane associated protein disulfide isomerase
- Mary
Jo Murnane, PhD, Program Admissions Chair
- Associate
Professor of Pathology & Laboratory Medicine, Assistant Research
Professor of Biochemistry
- Tumor
markers within a proteolytic cascade in tumorigenesis
- Neil
Ruderman, Ph.D., D.Phil.
- Professor
of Physiology.
- Insulin
action, gene expression, and diacylglycerol protein kinase C in
skeletal muscle.
- Hughes
J. P. Ryser, MD
- Professor
of Pathology & Laboratory Medicine, Pharmacology, and Biochemistry
- Plasma
membrane in translocation of diphtheria toxin; entry of HIV virus
into cells
- Julie
H. Sandell, Ph.D.
- Associate
Professor of Anatomy and Neurobiology
- Development
and inherited degeneration in zebrafish and primate retina.
- Barbara
Schreiber, PhD
- Associate
Professor of Biochemistry
- Atherosclerosis
and aortic smooth-muscle cells; the effect of atherogenic lipoproteins
on cell proliferation and biosynthesis of collagens and apolipoproteins
- Jacqueline
Sharon, PhD
- Professor
of Pathology & Laboratory Medicine
- Generation
and use of polyclonal antibody libraries for therapeutics and
diagnostics; soluble factors controling tumor growth.
- Phillip
Stone, PhD
- Professor
of Biochemistry
- The
connective-tissue protein, elastin; its enzymatic destruction
and repair in vitro and in vivo, associated with pathologic processes
- Guillermo
Taccioli, PhD
- Assistant
Professor of Microbiology
- Lymphocyte
development; V(D) J recombination; DNA repair
- Sam
Thiagalingam, PhD
- Assistant
Professor of Medicine-Genetics and Pathology and Laboratory Medicine
- Molecular
genetic and biochemical analysis of lung cancer.
- Keith
Tornheim, PhD
- Associate
Professor of Biochemistry
- Metabolic
oscillations in fuel stimulated insulin secretion from pancreatic
beta-cells; altered fuel metabolism and nitric oxide production
in vascular disease in diabetes
- Vickery
E. Trinkaus-Randall, Ph.D., Program Director
- Associate
Professor of Ophthalmology, Associate Professor of Biochemistry
- Regulation
of proteoglycans in response to growth factors and regulation
of calcium signaling and phosphorylation in response to injury
- Gregory
A. Viglianti, Ph.D.
- Assistant
Professor of Microbiology.
- Molecular
biology of HIV-1; the role of virus-host cell interactions in
pathogenesis.
- Vassilis
I. Zannis, PhD
- Professor
of Biochemistry
- Role
of apoE in the pathogenesis of Alzheimer's disease.
- R.
Andrew Zoeller, Ph.D., Assistant Program Director
- Associate
Professor of Biophysics, Assistant Research Professor of Biochemistry
and Medicine
- Use
of somatic cell genetics to define roles of lipids in stroke,
myocardial infarct and neuromuscular diseases.
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