Molecular Medicine
List of Courses

GMS MM 701 Genetics and Epidemiology Of Disease
Prereq: consent of instructor. This course will address the genetic basis of human disease and the techniques for investigation within this area of research. Topics will include molecular genetics, developmental genetics, population genetics, cancer genetics, genetic epidemiology, and clinical genetics from the perspective of research study design and disease mecha-nisms. Farrer. 2 cr, 1st sem.

GMS MM 703 Cancer Biology
Prereq: consent of instructor. This course will begin with an historical perspective; review the major mechanistic pathways relating to oncogenes, antioncogenes, cell cycle control, repair, and apoptosis; discuss standard and experimental principles of cancer treatment; and conclude with a discussion of cancer epidemiology and health policy issues that affect all basic and translational cancer research. Seldin. 2 cr, 1st sem.

GMS MM 705 Immunity and Infection
Prereq: consent of instructor. The Immunity and Infection course is designed to highlight the application of basic immunological concepts and molecular mechanisms that underlie conditions of immune dysfunction and immune responses to specific microorganisms and viruses. Measurements of immune system integrity that provide the basis for diagnosis will be examined in detail. Immunotherapies that encompass vaccine strategies, cytokine administration, bone marrow transplantation, peptide administration, oral tolerance, anti-idiotype treatment, and gene therapy will be discussed. T. Rothstein. 2 cr, 1st sem.

GMS MM 707 Organ System Diseases
Prereq: consent of instructor. The Organ System Diseases block is devoted to an exploration of contemporary research on the molecular basis of diseases that do not clearly fit into the rubrics of the first three blocks. Loscalzo. 2 cr, 1st sem.

GMS MM 710 Molecules to Molecular Therapeutics
Prereq: consent of the instructor. This course is designed to provide instruction in all aspects of the translation of basic research observations into clinical applications, using a case study model. The first case study will focus on sickle cell anemia. Lectures will review the molecular genetics of the disease and explore animal models for study of sickle cell anemia and will include laboratory exercises as appropriate. The course will address treatment strategies for sickle cell disease, including pharmacologic manipulation of globin gene expression, structural biology and rational drug design, and gene therapy. Additional topics related to clinical trials development will be covered including ethical issues, regulatory affairs, statistical considerations in clinical research, and outcome analysis. Required of all molecular medicine graduate students. Loscalzo. 4 cr, 2nd sem.