Molecular Medicine
List of Courses
First
Semester
The
Molecular Basis of Disease core curriculum is comprised of four
2-credit courses as follows:
GMS
MM 701 Genetics
and Epidemiology of Disease
GMS
MM 703 Cancer
Biology
GMS
MM 705 Immunity
and Infection
GMS
MM 707 Organ
System Diseases
Three
out of the four core courses listed above are required of all molecular
medicine students.
Second
Semester
The
second semester molecular medicine course is GMS
MM 710 Molecule
to Man: The Translation of Molecular Observations to Clinical Implementation
(4
cr).
Course
Descriptions
GMS
MM 701 Genetics and Epidemiology Of Disease
Prereq: consent of instructor. This course will address the genetic
basis of human disease and the techniques for investigation within this
area of research. Topics will include molecular genetics, developmental
genetics, population genetics, cancer genetics, genetic epidemiology,
and clinical genetics from the perspective of research study design
and disease mechanisms. Farrer. 2 cr, 1st sem.
GMS
MM 703 Cancer Biology Prereq:
consent of instructor. This course will begin with an historical perspective;
review the major mechanistic pathways relating to oncogenes, antioncogenes,
cell cycle control, repair, and apoptosis; discuss standard and experimental
principles of cancer treatment; and conclude with a discussion of cancer
epidemiology and health policy issues that affect all basic and translational
cancer research. Seldin. 2 cr, 1st sem.
GMS
MM 705 Immunity and Infection
Prereq: consent of instructor. The Immunity and Infection course is
designed to highlight the application of basic immunological concepts
and molecular mechanisms that underlie conditions of immune dysfunction
and immune responses to specific microorganisms and viruses. Measurements
of immune system integrity that provide the basis for diagnosis will
be examined in detail. Immunotherapies that encompass vaccine strategies,
cytokine administration, bone marrow transplantation, peptide administration,
oral tolerance, anti-idiotype treatment, and gene therapy will be discussed.
T. Rothstein. 2 cr, 1st sem.
GMS
MM 707 Organ System Diseases
Prereq: consent of instructor. The Organ System Diseases block is devoted
to an exploration of contemporary research on the molecular basis of
diseases that do not clearly fit into the rubrics of the first three
blocks. Loscalzo. 2 cr, 1st sem.
GMS
MM 710 Molecule to Man: The Translation
of Molecular Observations to the Clinical Implementation
Prereq: consent of the instructor. This course is designed to provide
instruction in all aspects of the translation of basic research observations
into clinical applications, using a case study model. The first case
study will focus on sickle cell anemia. Lectures will review the molecular
genetics of the disease and explore animal models for study of sickle
cell anemia and will include laboratory exercises as appropriate. The
course will address treatment strategies for sickle cell disease, including
pharmacologic manipulation of globin gene expression, structural biology
and rational drug design, and gene therapy. Additional topics related
to clinical trials development will be covered including ethical issues,
regulatory affairs, statistical considerations in clinical research,
and outcome analysis. Required of all molecular medicine graduate students.
Loscalzo. 4 cr, 2nd sem.
